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Gene : TNFRSF1B Homo sapiens

Name  ? TNF receptor superfamily member 1B Cytological Location  1p36.22
Brief Description  TNF receptor superfamily member 1B
description  The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. The function of IAPs in TNF-receptor signalling is unknown, however, c-IAP1 is thought to potentiate TNF-induced apoptosis by the ubiquitination and degradation of TNF-receptor-associated factor 2, which mediates anti-apoptotic signals. Knockout studies in mice also suggest a role of this protein in protecting neurons from apoptosis by stimulating antioxidative pathways. [provided by RefSeq, Jul 2008]
  • synonyms:
  • TNF-R75,
  • TNFR1B,
  • OTTHUMG00000001829,
  • NM_001066,
  • p75,
  • tumor necrosis factor receptor superfamily, member 1B,
  • TNFR2,
  • p75,
  • HGNC:11917,
  • TNFR2,
  • TBPII,
  • TNF-R-II,
  • TNFR80,
  • CD120b,
  • TNFBR,
  • uc001att.4,
  • M32315,
  • TNFBR,
  • TNFR80,
  • TNF-R75,
  • TNF-R-II,
  • p75TNFR,
  • CD120b
  • identifiers:
  • 7133,
  • ENSG00000028137,

Genome feature

Region: gene ? Length: 42275  
Location: 1:12166948-12209222 Cyto location: 1p36.22

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0 Diseases

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56 SN Ps

5 Cross References

17 Data Sets

2 Homologues

0 Located Features

97 Rna Seq Results