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Gene : TOP2B Homo sapiens

Name  ? DNA topoisomerase II beta Cytological Location  3p24.2
Brief Description  DNA topoisomerase II beta
Description  This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, beta, is localized to chromosome 3 and the alpha form is localized to chromosome 17. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2016]
  • synonyms:
  • top2beta,
  • NM_001068,
  • HGNC:11990,
  • X68060,
  • TOP2B,
  • TOPIIB,
  • topoisomerase (DNA) II beta 180kDa,
  • OTTHUMG00000155596,
  • uc003cdj.4
  • identifiers:
  • 7155,
  • ENSG00000077097,
  • TOP2B

Genome feature

Region: gene ? Length: 66987  
Location: 3:25597905-25664891 reverse strand Cyto location: 3p24.2


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Gene -> HPO annotation (Human Phenotype Ontology)

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Proteins

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SNPs

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Disease

0 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

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Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

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Expression

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Other

852 SN Ps

5 Cross References

17 Data Sets

7 Homologues

0 Located Features

97 Rna Seq Results