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Gene : TOP3A Homo sapiens

Name  ? DNA topoisomerase III alpha Cytological Location  17p11.2
Brief Description  DNA topoisomerase III alpha
Description  This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus reducing the number of supercoils and altering the topology of DNA. This enzyme forms a complex with BLM which functions in the regulation of recombination in somatic cells. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2016]
  • synonyms:
  • HGNC:11992,
  • ZGRF7,
  • TOP3,
  • TOP3,
  • ZGRF7,
  • NM_001320759,
  • U43431,
  • OTTHUMG00000059391,
  • PEOB5,
  • zinc finger, GRF-type containing 7,
  • uc002gsx.1,
  • topoisomerase (DNA) III alpha,
  • TOP3A
  • identifiers:
  • 7156,
  • ENSG00000177302,
  • TOP3A

Genome feature

Region: gene ? Length: 45039  
Location: 17:18269958-18314996 reverse strand Cyto location: 17p11.2

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Gene Ontology Displayer

Gene --> GO terms.

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


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Gene --> Chromosomal location.

Gene --> GO terms.

Gene --> Overlapping genes.


Gene --> Proteins.


Gene Report --> GWAS hit


2 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


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Gene --> Physical and Genetic Interactions


Gene(s) --> Significant SNPs (GTex data)

Gene Ontology

Gene --> GO terms.



3753 SN Ps

5 Cross References

19 Data Sets

6 Homologues

0 Located Features

97 Rna Seq Results