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Gene : C4B Homo sapiens

Name  ? complement C4B (Chido blood group) Cytological Location  6p21.33
Brief Description  complement C4B (Chido blood group)
Description  This gene encodes the basic form of complement factor 4, part of the classical activation pathway. The protein is expressed as a single chain precursor which is proteolytically cleaved into a trimer of alpha, beta, and gamma chains prior to secretion. The trimer provides a surface for interaction between the antigen-antibody complex and other complement components. The alpha chain may be cleaved to release C4 anaphylatoxin, a mediator of local inflammation. Deficiency of this protein is associated with systemic lupus erythematosus. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. Varying haplotypes of this gene cluster exist, such that individuals may have 1, 2, or 3 copies of this gene. In addition, this gene exists as a long form and a short form due to the presence or absence of a 6.4 kb endogenous HERV-K retrovirus in intron 9. [provided by RefSeq, Jul 2008]
  • synonyms:
  • C4B_2,
  • C4B1,
  • C4B3,
  • C4B2,
  • complement component 4B (Chido blood group),
  • C4B12,
  • CPAMD3,
  • OTTHUMG00000031187,
  • AF019413,
  • CO4,
  • HGNC:1324,
  • C4B,
  • C4B1,
  • CO4,
  • C4F,
  • CPAMD3,
  • NM_001002029,
  • complement component 4B,
  • C4F,
  • C4B5,
  • CH,
  • C4B3,
  • CH,
  • C4BD,
  • uc011dpd.3
  • identifiers:
  • 721,
  • ENSG00000224389,
  • C4B

Genome feature

Region: gene ? Length: 20624  
Location: 6:32014795-32035418 Cyto location: 6p21.33


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1 Diseases

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28197 SN Ps

5 Cross References

18 Data Sets

14 Homologues

0 Located Features

97 Rna Seq Results