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Gene : C4BPB Homo sapiens

Name  ? complement component 4 binding protein beta Cytological Location  1q32.1
Brief Description  complement component 4 binding protein beta
Description  This gene encodes a member of a superfamily of proteins composed predominantly of tandemly arrayed short consensus repeats of approximately 60 amino acids. A single, unique beta-chain encoded by this gene assembles with seven identical alpha-chains into the predominant isoform of C4b-binding protein, a multimeric protein that controls activation of the complement cascade through the classical pathway. C4b-binding protein has a regulatory role in the coagulation system also, mediated through the beta-chain binding of protein S, a vitamin K-dependent protein that serves as a cofactor of activated protein C. The genes encoding both alpha and beta chains are located adjacent to each other on human chromosome 1 in the regulator of complement activation gene cluster. Alternative splicing gives rise to multiple transcript variants. [provided by RefSeq, Jul 2008]
  • synonyms:
  • OTTHUMG00000036035,
  • C4b binding protein, beta chain,
  • C4BP,
  • L11245,
  • complement component 4 binding protein, beta chain,
  • C4BP,
  • complement component 4-binding protein, beta,
  • uc057oyu.1,
  • C4BPB,
  • HGNC:1328,
  • NM_000716
  • identifiers:
  • 725,
  • ENSG00000123843,
  • C4BPB

Genome feature

Region: gene ? Length: 11199  
Location: 1:207088795-207099993 Cyto location: 1q32.1


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Disease

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Other

460 SN Ps

5 Cross References

17 Data Sets

0 Homologues

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97 Rna Seq Results