help  | about  | cite  | software

Gene : DDR1 Homo sapiens

Name  ? discoidin domain receptor tyrosine kinase 1 Cytological Location  6p21.33
Brief Description  discoidin domain receptor tyrosine kinase 1
Description  Receptor tyrosine kinases play a key role in the communication of cells with their microenvironment. These kinases are involved in the regulation of cell growth, differentiation and metabolism. The protein encoded by this gene belongs to a subfamily of tyrosine kinase receptors with homology to Dictyostelium discoideum protein discoidin I in their extracellular domain, and that are activated by various types of collagen. Expression of this protein is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, it has been shown to be significantly overexpressed in several human tumors. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2011]
  • synonyms:
  • NM_013994,
  • HGNC:2730,
  • PTK3,
  • uc011faa.3,
  • MCK10,
  • EDDR1,
  • CAK,
  • OTTHUMG00000031236,
  • PTK3A,
  • NEP,
  • DDR,
  • TRKE,
  • X99031,
  • discoidin domain receptor family, member 1,
  • DDR1,
  • EDDR1,
  • CAK,
  • CD167,
  • CD167,
  • PTK3A,
  • NTRK4,
  • RTK6,
  • NEP,
  • HGK2,
  • RTK6,
  • NTRK4
  • identifiers:
  • 780,
  • ENSG00000204580,
  • DDR1

Genome feature

Region: gene ? Length: 19199  
Location: 6:30880958-30900156 Cyto location: 6p21.33


Uni Prot Comments Displayer

Protein Atlas Displayer

Gene Expression Atlas Tissues Displayer

Gene Expression Atlas Diseases Displayer

Publication Counts Displayer

Curated Proteins Displayer

Function

Gene Ontology Displayer

Gene --> GO terms.

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

Genomics

J Browse Displayer

Gene Structure Displayer

Overlapping Features Displayer

Mouse Alleles Displayer

Gene --> Chromosomal location.

Gene --> GO terms.

Gene --> Overlapping genes.

Proteins

Gene --> Proteins.

SNPs

Gene Report --> GWAS hit

Disease

0 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

Homology

Homologue Displayer

Interactions

Cytoscape Network Displayer

Gene --> Physical and Genetic Interactions

Expression

Gene(s) --> Significant SNPs (GTex data)

Gene Ontology

Gene --> GO terms.

 

Other

3753 SN Ps

5 Cross References

15 Data Sets

3 Homologues

0 Located Features

97 Rna Seq Results