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Gene : DDR1 Homo sapiens

Name  ? discoidin domain receptor tyrosine kinase 1 Cytological Location  6p21.33
Brief Description  discoidin domain receptor tyrosine kinase 1
Description  Receptor tyrosine kinases play a key role in the communication of cells with their microenvironment. These kinases are involved in the regulation of cell growth, differentiation and metabolism. The protein encoded by this gene belongs to a subfamily of tyrosine kinase receptors with homology to Dictyostelium discoideum protein discoidin I in their extracellular domain, and that are activated by various types of collagen. Expression of this protein is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, it has been shown to be significantly overexpressed in several human tumors. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2011]
  • synonyms:
  • NM_013994,
  • HGNC:2730,
  • PTK3,
  • uc011faa.3,
  • MCK10,
  • EDDR1,
  • CAK,
  • OTTHUMG00000031236,
  • PTK3A,
  • NEP,
  • DDR,
  • TRKE,
  • X99031,
  • discoidin domain receptor family, member 1,
  • DDR1,
  • EDDR1,
  • CAK,
  • CD167,
  • CD167,
  • PTK3A,
  • NTRK4,
  • RTK6,
  • NEP,
  • HGK2,
  • RTK6,
  • NTRK4
  • identifiers:
  • 780,
  • ENSG00000204580,
  • DDR1

Genome feature

Region: gene ? Length: 19199  
Location: 6:30880958-30900156 Cyto location: 6p21.33

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0 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

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Mouse Gene --> Allele [Phenotype]


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Gene(s) --> Significant SNPs (GTex data)

Gene Ontology

Gene --> GO terms.



3753 SN Ps

5 Cross References

15 Data Sets

3 Homologues

0 Located Features

97 Rna Seq Results