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Gene : CAD Homo sapiens

Name  ? carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase Cytological Location  2p23.3
Brief Description  carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
Description  The de novo synthesis of pyrimidine nucleotides is required for mammalian cells to proliferate. This gene encodes a trifunctional protein which is associated with the enzymatic activities of the first 3 enzymes in the 6-step pathway of pyrimidine biosynthesis: carbamoylphosphate synthetase (CPS II), aspartate transcarbamoylase, and dihydroorotase. This protein is regulated by the mitogen-activated protein kinase (MAPK) cascade, which indicates a direct link between activation of the MAPK cascade and de novo biosynthesis of pyrimidine nucleotides. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]
  • synonyms:
  • HGNC:1424,
  • GATD4,
  • EIEE50,
  • CDG1Z,
  • CAD,
  • GATD4,
  • OTTHUMG00000097070,
  • NM_001306079,
  • D78586,
  • uc002rji.4
  • identifiers:
  • 790,
  • ENSG00000084774,
  • CAD

Genome feature

Region: gene ? Length: 26575  
Location: 2:27217369-27243943 Cyto location: 2p23.3


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Disease

1 Diseases

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3753 SN Ps

5 Cross References

20 Data Sets

7 Homologues

0 Located Features

97 Rna Seq Results