help  | about  | cite  | software

Gene : BRCC3 Homo sapiens

Name  ? BRCA1/BRCA2-containing complex subunit 3 Cytological Location  Xq28
Brief Description  BRCA1/BRCA2-containing complex subunit 3
Description  This gene encodes a subunit of the BRCA1-BRCA2-containing complex (BRCC), which is an E3 ubiquitin ligase. This complex plays a role in the DNA damage response, where it is responsible for the stable accumulation of BRCA1 at DNA break sites. The component encoded by this gene can specifically cleave Lys 63-linked polyubiquitin chains, and it regulates the abundance of these polyubiquitin chains in chromatin. The loss of this gene results in abnormal angiogenesis and is associated with syndromic moyamoya, a cerebrovascular angiopathy. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 5. [provided by RefSeq, Jun 2011]
  • synonyms:
  • Lys-63-specific deubiquitinase,
  • BRCA1/BRCA2-containing complex, subunit 3,
  • BRCC36,
  • X64643,
  • HGNC:24185,
  • C6.1A,
  • uc065cjq.1,
  • OTTHUMG00000022658,
  • CXorf53,
  • chromosome X open reading frame 53,
  • CXorf53,
  • BRCC3,
  • C6.1A,
  • NM_024332,
  • BRCC36
  • identifiers:
  • 79184,
  • ENSG00000185515,
  • BRCC3

Genome feature

Region: gene ? Length: 55364  
Location: X:155071403-155126766 Cyto location: Xq28

Uni Prot Comments Displayer

Protein Atlas Displayer

Gene Expression Atlas Tissues Displayer

Gene Expression Atlas Diseases Displayer

Publication Counts Displayer

Curated Proteins Displayer


Gene Ontology Displayer

Gene --> GO terms.

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


J Browse Displayer

Gene Structure Displayer

Overlapping Features Displayer

Mouse Alleles Displayer

Gene --> Chromosomal location.

Gene --> GO terms.

Gene --> Overlapping genes.


Gene --> Proteins.


Gene Report --> GWAS hit


0 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


Homologue Displayer


Cytoscape Network Displayer

Gene --> Physical and Genetic Interactions


Gene(s) --> Significant SNPs (GTex data)

Gene Ontology

Gene --> GO terms.



3753 SN Ps

5 Cross References

15 Data Sets

4 Homologues

0 Located Features

97 Rna Seq Results