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Gene : CDC73 Homo sapiens

Name  ? cell division cycle 73 Cytological Location  1q31.2
Brief Description  cell division cycle 73
Description  This gene encodes a tumor suppressor that is involved in transcriptional and post-transcriptional control pathways. The protein is a component of the the PAF protein complex, which associates with the RNA polymerase II subunit POLR2A and with a histone methyltransferase complex. This protein appears to facilitate the association of 3' mRNA processing factors with actively-transcribed chromatin. Mutations in this gene have been linked to hyperparathyroidism-jaw tumor syndrome, familial isolated hyperparathyroidism, and parathyroid carcinoma. [provided by RefSeq, Jul 2009]
  • synonyms:
  • FIHP,
  • AF312865,
  • cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae),
  • HYX,
  • HRPT2,
  • uc001gtb.4,
  • Familial isolated hyperparathyroidism,
  • HRPT1,
  • C1orf28,
  • hyperparathyroidism 2 (with jaw tumor),
  • OTTHUMG00000035676,
  • parafibromin,
  • FIHP,
  • CDC73,
  • NM_024529,
  • HPTJT,
  • hyperparathyroidism 1,
  • C1orf28,
  • HGNC:16783,
  • HRPT1,
  • HRPT2,
  • Paf1/RNA polymerase II complex component,
  • chromosome 1 open reading frame 28
  • identifiers:
  • 79577,
  • ENSG00000134371,
  • CDC73

Genome feature

Region: gene ? Length: 132785  
Location: 1:193122031-193254815 Cyto location: 1q31.2

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3 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


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Gene(s) --> Significant SNPs (GTex data)

Gene Ontology

Gene --> GO terms.



332 SNPs

5 Cross References

19 Data Sets

7 Homologues

0 Located Features

97 Rna Seq Results