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Gene : CXXC4 Homo sapiens

Name  ? CXXC finger protein 4 Cytological Location  4q24
Brief Description  CXXC finger protein 4
Description  This gene encodes a CXXC-type zinc finger domain-containing protein that functions as an antagonist of the canonical wingless/integrated signaling pathway. The encoded protein negatively regulates wingless/integrated signaling through interaction with the post synaptic density protein/ Drosophila disc large tumor suppressor/ zonula occludens-1 protein domain of Dishevelled, a scaffolding protein required for the stabilization of the transcriptional co-activator beta-catenin. In addition, the CXXC domain of this protein has been shown to bind unmethylated CpG dinucleotides, localize to promoters and CpG islands, and interact with the catalytic domain of methylcytosine dioxygenase ten-eleven-translocation 2, an iron and alpha-ketoglutarate-dependent dioxygenase that modifies the methylation status of DNA. In humans, a mutation in this gene has been associated with development of malignant renal cell carcinoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
  • synonyms:
  • NM_025212,
  • OTTHUMG00000131121,
  • IDAX,
  • uc003hxf.3,
  • HGNC:24593,
  • Dvl-binding protein IDAX (inhibition of the Dvl and Axin complex),
  • IDAX,
  • CXXC4
  • identifiers:
  • 80319,
  • ENSG00000168772,
  • CXXC4

Genome feature

Region: gene ? Length: 26660  
Location: 4:104468308-104494967 reverse strand Cyto location: 4q24


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Disease

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Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

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0 Pathways

339 SN Ps

5 Cross References

14 Data Sets

0 Homologues

0 Located Features

97 Rna Seq Results