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Gene : ITIH5 Homo sapiens

Name  ? inter-alpha-trypsin inhibitor heavy chain 5 Cytological Location  10p14
Brief Description  inter-alpha-trypsin inhibitor heavy chain 5
Description  This gene encodes a heavy chain component of one of the inter-alpha-trypsin inhibitor (ITI) family members. ITI proteins are involved in extracellular matrix stabilization and in the prevention of tumor metastasis. They are also structurally related plasma serine protease inhibitors and are composed of a light chain and varying numbers of heavy chains. This family member is thought to function as a tumor suppressor in breast and thyroid cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]
  • synonyms:
  • HGNC:21449,
  • ITI-HC5,
  • MGC10848,
  • ITIH5,
  • PP14776,
  • inter-alpha-trypsin inhibitor heavy chain family, member 5,
  • OTTHUMG00000017635,
  • NM_030569,
  • inter-alpha (globulin) inhibitor H5,
  • uc031vwl.2
  • identifiers:
  • 80760,
  • ENSG00000123243,
  • ITIH5

Genome feature

Region: gene ? Length: 107729  
Location: 10:7559270-7666998 reverse strand Cyto location: 10p14

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0 Pathways

Gene --> GO terms.

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


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Gene --> Chromosomal location.

Gene --> GO terms.

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Gene --> Proteins.


Gene Report --> GWAS hit


0 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


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Gene --> Physical and Genetic Interactions


Gene(s) --> Significant SNPs (GTex data)

Gene Ontology

Gene --> GO terms.



0 Pathways

893 SN Ps

5 Cross References

17 Data Sets

2 Homologues

0 Located Features

97 Rna Seq Results