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Gene : HMGA2 Homo sapiens

Name  ? high mobility group AT-hook 2 Cytological Location  12q14.3
Brief Description  high mobility group AT-hook 2
Description  This gene encodes a protein that belongs to the non-histone chromosomal high mobility group (HMG) protein family. HMG proteins function as architectural factors and are essential components of the enhancesome. This protein contains structural DNA-binding domains and may act as a transcriptional regulating factor. Identification of the deletion, amplification, and rearrangement of this gene that are associated with myxoid liposarcoma suggests a role in adipogenesis and mesenchymal differentiation. A gene knock out study of the mouse counterpart demonstrated that this gene is involved in diet-induced obesity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
  • synonyms:
  • HMGA2,
  • uc001ssx.4,
  • high-mobility group (nonhistone chromosomal) protein isoform I-C,
  • HGNC:5009,
  • HMGIC,
  • LIPO,
  • HMGI-C,
  • LIPO,
  • OTTHUMG00000168936,
  • STQTL9,
  • HMGIC,
  • U28754,
  • BABL,
  • NM_003483,
  • BABL
  • identifiers:
  • 8091,
  • ENSG00000149948,
  • HMGA2

Genome feature

Region: gene ? Length: 141832  
Location: 12:65824460-65966291 Cyto location: 12q14.3


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Proteins

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SNPs

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Disease

1 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

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Gene -> HPO annotation (Human Phenotype Ontology)

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Expression

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Other

102 SN Ps

5 Cross References

19 Data Sets

5 Homologues

0 Located Features

97 Rna Seq Results