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Gene : CDK2AP1 Homo sapiens

Name  ? cyclin dependent kinase 2 associated protein 1 Cytological Location  12q24.31
Brief Description  cyclin dependent kinase 2 associated protein 1
Description  The protein encoded by this gene is a cyclin-dependent kinase 2 (CDK2) -associated protein which is thought to negatively regulate CDK2 activity by sequestering monomeric CDK2, and targeting CDK2 for proteolysis. This protein was found to also interact with DNA polymerase alpha/primase and mediate the phosphorylation of the large p180 subunit, which suggests a regulatory role in DNA replication during the S-phase of the cell cycle. This protein also forms a core subunit of the nucleosome remodeling and histone deacetylation (NURD) complex that epigenetically regulates embryonic stem cell differentiation. This gene thus plays a role in both cell-cycle and epigenetic regulation. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2012]
  • synonyms:
  • uc001ueq.5,
  • CDK2-associated protein 1,
  • AB006077,
  • ST19,
  • DORC1,
  • DORC1,
  • p12DOC-1,
  • doc-1,
  • HGNC:14002,
  • NM_004642,
  • p12DOC-1,
  • CDK2AP1,
  • DOC1,
  • OTTHUMG00000168854,
  • DOC1,
  • doc-1,
  • ST19
  • identifiers:
  • 8099,
  • ENSG00000111328,
  • CDK2AP1

Genome feature

Region: gene ? Length: 11271  
Location: 12:123260970-123272240 reverse strand Cyto location: 12q24.31


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Gene --> GO terms.

Gene -> HPO annotation (Human Phenotype Ontology)

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Proteins

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SNPs

Gene Report --> GWAS hit

Disease

0 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

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Expression

Gene(s) --> Significant SNPs (GTex data)

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Other

0 Pathways

3753 SN Ps

5 Cross References

16 Data Sets

5 Homologues

0 Located Features

97 Rna Seq Results