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Gene : HM13 Homo sapiens

Name  ? histocompatibility minor 13 Cytological Location  20q11.21
Brief Description  histocompatibility minor 13
Description  The protein encoded by this gene, which localizes to the endoplasmic reticulum, catalyzes intramembrane proteolysis of some signal peptides after they have been cleaved from a preprotein. This activity is required to generate signal sequence-derived human lymphocyte antigen-E epitopes that are recognized by the immune system, and to process hepatitis C virus core protein. The encoded protein is an integral membrane protein with sequence motifs characteristic of the presenilin-type aspartic proteases. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
  • synonyms:
  • SPPL1,
  • OTTHUMG00000032175,
  • presenilin-like protein 3,
  • H13,
  • HM13,
  • SPPL1,
  • PSENL3,
  • PSL3,
  • H13,
  • IMP1,
  • signal peptide peptidase like 1,
  • HGNC:16435,
  • NM_178580,
  • IMP1,
  • IMPAS-1,
  • PSENL3,
  • MSTP086,
  • PSL3,
  • signal peptide peptidase beta,
  • IMPAS,
  • AL110115,
  • intramembrane protease,
  • uc002wwc.5,
  • SPP,
  • IMPAS,
  • SPP,
  • dJ324O17.1
  • identifiers:
  • 81502,
  • ENSG00000101294,
  • HM13

Genome feature

Region: gene ? Length: 55158  
Location: 20:31514410-31569567 Cyto location: 20q11.21

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0 Pathways

Gene --> GO terms.

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


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Gene --> Chromosomal location.

Gene --> GO terms.

Gene --> Overlapping genes.


Gene --> Proteins.


Gene Report --> GWAS hit


0 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


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Gene --> Physical and Genetic Interactions


Gene(s) --> Significant SNPs (GTex data)

Gene Ontology

Gene --> GO terms.



0 Pathways

3753 SN Ps

5 Cross References

15 Data Sets

7 Homologues

0 Located Features

97 Rna Seq Results