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Gene : CAMLG Homo sapiens

Name  ? calcium modulating ligand Cytological Location  5q31.1
Brief Description  calcium modulating ligand
Description  The immunosuppressant drug cyclosporin A blocks a calcium-dependent signal from the T-cell receptor (TCR) that normally leads to T-cell activation. When bound to cyclophilin B, cyclosporin A binds and inactivates the key signaling intermediate calcineurin. The protein encoded by this gene functions similarly to cyclosporin A, binding to cyclophilin B and acting downstream of the TCR and upstream of calcineurin by causing an influx of calcium. This integral membrane protein appears to be a new participant in the calcium signal transduction pathway, implicating cyclophilin B in calcium signaling, even in the absence of cyclosporin. [provided by RefSeq, Jul 2008]
  • synonyms:
  • GET2,
  • calcium-modulating cyclophilin ligand,
  • CAML,
  • AF068179.1,
  • HGNC:1471,
  • calcium-signal modulating cyclophilin ligand,
  • NM_001745,
  • CAML,
  • uc003kzt.4,
  • CAMLG,
  • OTTHUMG00000129116,
  • cyclophilin B-binding protein,
  • GET2
  • identifiers:
  • 819,
  • ENSG00000164615,

Genome feature

Region: gene ? Length: 13610  
Location: 5:134738548-134752157 Cyto location: 5q31.1

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3740 SN Ps

5 Cross References

15 Data Sets

3 Homologues

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97 Rna Seq Results