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Gene : CAPN6 Homo sapiens

Name  ? calpain 6 Cytological Location  Xq23
Brief Description  calpain 6
Description  Calpains are ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large subunit possesses a cysteine protease domain, and both subunits possess calcium-binding domains. Calpains have been implicated in neurodegenerative processes, as their activation can be triggered by calcium influx and oxidative stress. The protein encoded by this gene is highly expressed in the placenta. Its C-terminal region lacks any homology to the calmodulin-like domain of other calpains. The protein lacks critical active site residues and thus is suggested to be proteolytically inactive. The protein may play a role in tumor formation by inhibiting apoptosis and promoting angiogenesis. [provided by RefSeq, Nov 2009]
  • synonyms:
  • HGNC:1483,
  • CalpM,
  • AF029232,
  • CANPX,
  • CAPNX,
  • uc004epc.3,
  • CANPX,
  • CAPN6,
  • CAPNX,
  • DJ914P14.1,
  • CalpM,
  • NM_014289,
  • OTTHUMG00000022203
  • identifiers:
  • 827,
  • ENSG00000077274,
  • CAPN6

Genome feature

Region: gene ? Length: 25385  
Location: X:111245099-111270483 reverse strand Cyto location: Xq23


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Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

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Proteins

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SNPs

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Disease

0 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

Homology

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Expression

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Other

644 SN Ps

5 Cross References

15 Data Sets

15 Homologues

0 Located Features

97 Rna Seq Results