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Gene : ARID1A Homo sapiens

Name  ? AT-rich interaction domain 1A Cytological Location  1p36.11
Brief Description  AT-rich interaction domain 1A
Description  This gene encodes a member of the SWI/SNF family, whose members have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. It possesses at least two conserved domains that could be important for its function. First, it has a DNA-binding domain that can specifically bind an AT-rich DNA sequence known to be recognized by a SNF/SWI complex at the beta-globin locus. Second, the C-terminus of the protein can stimulate glucocorticoid receptor-dependent transcriptional activation. It is thought that the protein encoded by this gene confers specificity to the SNF/SWI complex and may recruit the complex to its targets through either protein-DNA or protein-protein interactions. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
  • synonyms:
  • ELD,
  • BAF250,
  • AB001895,
  • SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily f, member 1,
  • MRD14,
  • hOSA1,
  • B120,
  • C1orf4,
  • HGNC:11110,
  • BAF250a,
  • C10rf4,
  • SMARCF1,
  • CSS2,
  • NM_139135,
  • C1orf4,
  • uc001bmv.2,
  • AT rich interactive domain 1A (SWI-like),
  • OTTHUMG00000004004,
  • B120,
  • P270,
  • hELD,
  • OSA1,
  • SMARCF1,
  • BM029,
  • P270,
  • BAF250a,
  • AT rich interactive domain 1A (SWI- like),
  • BAF250,
  • ARID1A
  • identifiers:
  • 8289,
  • ENSG00000117713,
  • ARID1A

Genome feature

Region: gene ? Length: 86090  
Location: 1:26696015-26782104 Cyto location: 1p36.11

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1 Diseases

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194 SN Ps

5 Cross References

19 Data Sets

6 Homologues

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97 Rna Seq Results