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Gene : CAST Homo sapiens

Name  ? calpastatin Cytological Location  5q15
Brief Description  calpastatin
Description  The protein encoded by this gene is an endogenous calpain (calcium-dependent cysteine protease) inhibitor. It consists of an N-terminal domain L and four repetitive calpain-inhibition domains (domains 1-4), and it is involved in the proteolysis of amyloid precursor protein. The calpain/calpastatin system is involved in numerous membrane fusion events, such as neural vesicle exocytosis and platelet and red-cell aggregation. The encoded protein is also thought to affect the expression levels of genes encoding structural or regulatory proteins. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jun 2010]
  • synonyms:
  • AF327443,
  • HGNC:1515,
  • CAST,
  • OTTHUMG00000128413,
  • PLACK,
  • uc003kmd.4,
  • NM_173062,
  • BS-17
  • identifiers:
  • 831,
  • ENSG00000153113,
  • CAST

Genome feature

Region: gene ? Length: 112647  
Location: 5:96662037-96774683 Cyto location: 5q15


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Gene -> HPO annotation (Human Phenotype Ontology)

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Genomics

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Proteins

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SNPs

Gene Report --> GWAS hit

Disease

1 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

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Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

Homology

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Interactions

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Expression

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Other

3756 SN Ps

5 Cross References

19 Data Sets

3 Homologues

0 Located Features

97 Rna Seq Results