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Gene : AXIN2 Homo sapiens

Name  ? axin 2 Cytological Location  17q24.1
Brief Description  axin 2
Description  The Axin-related protein, Axin2, presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. In mouse, conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin. Apparently, the deregulation of beta-catenin is an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair. [provided by RefSeq, Jul 2008]
  • synonyms:
  • AF078165,
  • OTTHUMG00000179353,
  • AXIL,
  • conductin,
  • ODCRCS,
  • MGC126582,
  • HGNC:904,
  • NM_004655,
  • DKFZp781B0869,
  • AXIN2,
  • axil,
  • uc002jfi.4
  • identifiers:
  • 8313,
  • ENSG00000168646,
  • AXIN2

Genome feature

Region: gene ? Length: 33086  
Location: 17:65528563-65561648 reverse strand Cyto location: 17q24.1


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Disease

2 Diseases

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140 SN Ps

5 Cross References

19 Data Sets

6 Homologues

0 Located Features

97 Rna Seq Results