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Gene : CDC45 Homo sapiens

Name  ? cell division cycle 45 Cytological Location  22q11.21
Brief Description  cell division cycle 45
Description  The protein encoded by this gene was identified by its strong similarity with Saccharomyces cerevisiae Cdc45, an essential protein required to the initiation of DNA replication. Cdc45 is a member of the highly conserved multiprotein complex including Cdc6/Cdc18, the minichromosome maintenance proteins (MCMs) and DNA polymerase, which is important for early steps of DNA replication in eukaryotes. This protein has been shown to interact with MCM7 and DNA polymerase alpha. Studies of the similar gene in Xenopus suggested that this protein play a pivotal role in the loading of DNA polymerase alpha onto chromatin. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
  • synonyms:
  • uc002zpr.5,
  • cell division cycle 45 homolog (S. cerevisiae),
  • CDC45L,
  • CDC45L2,
  • AF053074,
  • PORC-PI-1,
  • MGORS7,
  • CDC45 cell division cycle 45-like (S. cerevisiae),
  • CDC45,
  • CDC45 (cell division cycle 45, S.cerevisiae, homolog)-like,
  • CDC45L2,
  • HGNC:1739,
  • NM_003504,
  • OTTHUMG00000150386,
  • CDC45L,
  • human CDC45
  • identifiers:
  • 8318,
  • ENSG00000093009,
  • CDC45

Genome feature

Region: gene ? Length: 41319  
Location: 22:19479294-19520612 Cyto location: 22q11.21

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1 Diseases

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219 SN Ps

5 Cross References

20 Data Sets

6 Homologues

0 Located Features

97 Rna Seq Results