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Gene : FZD6 Homo sapiens

Name  ? frizzled class receptor 6 Cytological Location  8q22.3
Brief Description  frizzled class receptor 6
Description  This gene represents a member of the 'frizzled' gene family, which encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The protein encoded by this family member contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, and seven transmembrane domains, but unlike other family members, this protein does not contain a C-terminal PDZ domain-binding motif. This protein functions as a negative regulator of the canonical Wnt/beta-catenin signaling cascade, thereby inhibiting the processes that trigger oncogenic transformation, cell proliferation, and inhibition of apoptosis. Alternative splicing results in multiple transcript variants, some of which do not encode a protein with a predicted signal peptide.[provided by RefSeq, Aug 2011]
  • synonyms:
  • uc003ylh.4,
  • frizzled (Drosophila) homolog 6,
  • HGNC:4044,
  • HFZ6,
  • FZ-6,
  • OTTHUMG00000164840,
  • NDNC10,
  • NDNC1,
  • AB012911,
  • frizzled homolog 6 (Drosophila),
  • FZ6,
  • NM_003506,
  • FZD6,
  • frizzled 6, seven transmembrane spanning receptor,
  • frizzled family receptor 6,
  • Hfz6
  • identifiers:
  • 8323,
  • ENSG00000164930,
  • FZD6

Genome feature

Region: gene ? Length: 34373  
Location: 8:103298494-103332866 Cyto location: 8q22.3

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1 Diseases

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Gene -> HPO annotation (Human Phenotype Ontology)

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3753 SN Ps

5 Cross References

19 Data Sets

6 Homologues

0 Located Features

97 Rna Seq Results