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Gene : CASP3 Homo sapiens

Name  ? caspase 3 Cytological Location  4q35.1
Brief Description  caspase 3
Description  The protein encoded by this gene is a cysteine-aspartic acid protease that plays a central role in the execution-phase of cell apoptosis. The encoded protein cleaves and inactivates poly(ADP-ribose) polymerase while it cleaves and activates sterol regulatory element binding proteins as well as caspases 6, 7, and 9. This protein itself is processed by caspases 8, 9, and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. [provided by RefSeq, Aug 2017]
  • synonyms:
  • CPP32,
  • NM_004346,
  • Yama,
  • CASP3,
  • HGNC:1504,
  • CPP32,
  • CPP32B,
  • apopain,
  • SCA-1,
  • uc003iwi.4,
  • BC016926,
  • caspase 3, apoptosis-related cysteine peptidase,
  • caspase 3, apoptosis-related cysteine protease,
  • CPP32B,
  • OTTHUMG00000133681
  • identifiers:
  • 836,
  • ENSG00000164305,
  • CASP3

Genome feature

Region: gene ? Length: 21752  
Location: 4:184627696-184649447 reverse strand Cyto location: 4q35.1

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Gene --> GO terms.

Gene -> HPO annotation (Human Phenotype Ontology)

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0 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


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Gene(s) --> Significant SNPs (GTex data)

Gene Ontology

Gene --> GO terms.



3740 SNPs

5 Cross References

16 Data Sets

5 Homologues

0 Located Features

97 Rna Seq Results