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Gene : CASP4 Homo sapiens

Name  ? caspase 4 Cytological Location  11q22.3
Brief Description  caspase 4
Description  This gene encodes a protein that is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain and a large and small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This caspase is able to cleave and activate its own precursor protein, as well as caspase 1 precursor. When overexpressed, this gene induces cell apoptosis. Alternative splicing results in transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]
  • synonyms:
  • ICH-2,
  • TX,
  • caspase 4, apoptosis-related cysteine peptidase,
  • caspase 4, apoptosis-related cysteine protease,
  • CASP4,
  • uc001pid.2,
  • Mih1,
  • TX,
  • NM_001225,
  • OTTHUMG00000166078,
  • Mih1/TX,
  • ICE(rel)II,
  • U25804,
  • HGNC:1505,
  • ICE(rel)II,
  • ICH-2
  • identifiers:
  • 837,
  • ENSG00000196954,
  • CASP4

Genome feature

Region: gene ? Length: 25731  
Location: 11:104942866-104968596 reverse strand Cyto location: 11q22.3

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Gene -> HPO annotation (Human Phenotype Ontology)

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0 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


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Gene(s) --> Significant SNPs (GTex data)

Gene Ontology

Gene --> GO terms.



3740 SNPs

5 Cross References

17 Data Sets

10 Homologues

0 Located Features

97 Rna Seq Results