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Gene : CASP5 Homo sapiens

Name  ? caspase 5 Cytological Location  11q22.3
Brief Description  caspase 5
Description  This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. Overexpression of the active form of this enzyme induces apoptosis in fibroblasts. Max, a central component of the Myc/Max/Mad transcription regulation network important for cell growth, differentiation, and apoptosis, is cleaved by this protein; this process requires Fas-mediated dephosphorylation of Max. The expression of this gene is regulated by interferon-gamma and lipopolysaccharide. Alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Aug 2010]
  • synonyms:
  • caspase 5, apoptosis-related cysteine protease,
  • caspase 5, apoptosis-related cysteine peptidase,
  • NM_004347,
  • uc010rva.2,
  • ICE(rel)III,
  • ICH-3,
  • ICE(rel)III,
  • HGNC:1506,
  • CASP5,
  • OTTHUMG00000048073
  • identifiers:
  • 838,
  • ENSG00000137757,
  • CASP5

Genome feature

Region: gene ? Length: 29660  
Location: 11:104994243-105023902 reverse strand Cyto location: 11q22.3

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0 Pathways

Gene --> GO terms.

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


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Gene --> Chromosomal location.

Gene --> GO terms.

Gene --> Overlapping genes.


Gene --> Proteins.


Gene Report --> GWAS hit


0 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


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Gene --> Physical and Genetic Interactions


Gene(s) --> Significant SNPs (GTex data)

Gene Ontology

Gene --> GO terms.



0 Pathways

795 SNPs

5 Cross References

14 Data Sets

10 Homologues

0 Located Features

97 Rna Seq Results