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Gene : CASP5 Homo sapiens

Name  ? caspase 5 Cytological Location  11q22.3
Brief Description  caspase 5
Description  This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. Overexpression of the active form of this enzyme induces apoptosis in fibroblasts. Max, a central component of the Myc/Max/Mad transcription regulation network important for cell growth, differentiation, and apoptosis, is cleaved by this protein; this process requires Fas-mediated dephosphorylation of Max. The expression of this gene is regulated by interferon-gamma and lipopolysaccharide. Alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Aug 2010]
  • synonyms:
  • ICE(rel)III,
  • caspase 5, apoptosis-related cysteine peptidase,
  • HGNC:1506,
  • OTTHUMG00000048073,
  • caspase 5, apoptosis-related cysteine protease,
  • uc010rva.2,
  • ICH-3,
  • ICE(rel)III,
  • CASP5,
  • NM_004347
  • identifiers:
  • 838,
  • ENSG00000137757,
  • CASP5

Genome feature

Region: gene ? Length: 29668  
Location: 11:104994235-105023902 reverse strand Cyto location: 11q22.3

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Gene -> HPO annotation (Human Phenotype Ontology)

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0 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


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Gene --> GO terms.



795 SN Ps

5 Cross References

15 Data Sets

19 Homologues

0 Located Features

97 Rna Seq Results