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Gene : BCAR3 Homo sapiens

Name  ? BCAR3 adaptor protein, NSP family member Cytological Location  1p22.1
Brief Description  BCAR3 adaptor protein, NSP family member
Description  Breast tumors are initially dependent on estrogens for growth and progression and can be inhibited by anti-estrogens such as tamoxifen. However, breast cancers progress to become anti-estrogen resistant. Breast cancer anti-estrogen resistance gene 3 was identified in the search for genes involved in the development of estrogen resistance. The gene encodes a component of intracellular signal transduction that causes estrogen-independent proliferation in human breast cancer cells. The protein contains a putative src homology 2 (SH2) domain, a hall mark of cellular tyrosine kinase signaling molecules, and is partly homologous to the cell division cycle protein CDC48. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]
  • synonyms:
  • breast cancer anti-estrogen resistance 3,
  • SH2D3B,
  • AND-34,
  • uc001dqb.5,
  • NM_001261408,
  • BCAR3, NSP family adaptor protein,
  • AND-34,
  • HGNC:973,
  • U92715,
  • BCAR3,
  • NSP2,
  • SH2D3B,
  • NSP2,
  • OTTHUMG00000010301
  • identifiers:
  • 8412,
  • ENSG00000137936,
  • BCAR3

Genome feature

Region: gene ? Length: 285479  
Location: 1:93561741-93847219 reverse strand Cyto location: 1p22.1


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5 Cross References

9 Data Sets

4 Homologues

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