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Gene : ANTXR1 Homo sapiens

Name  ? ANTXR cell adhesion molecule 1 Cytological Location  2p13.3
Brief Description  ANTXR cell adhesion molecule 1
Description  This gene encodes a type I transmembrane protein and is a tumor-specific endothelial marker that has been implicated in colorectal cancer. The encoded protein has been shown to also be a docking protein or receptor for Bacillus anthracis toxin, the causative agent of the disease, anthrax. The binding of the protective antigen (PA) component, of the tripartite anthrax toxin, to this receptor protein mediates delivery of toxin components to the cytosol of cells. Once inside the cell, the other two components of anthrax toxin, edema factor (EF) and lethal factor (LF) disrupt normal cellular processes. Three alternatively spliced variants that encode different protein isoforms have been described. [provided by RefSeq, Oct 2008]
  • synonyms:
  • FLJ21776,
  • TEM8,
  • uc002sfg.4,
  • ATR,
  • OTTHUMG00000129575,
  • FLJ10601,
  • NM_032208,
  • anthrax toxin receptor 1,
  • HGNC:21014,
  • TEM8,
  • ANTXR1,
  • tumor endothelial marker 8 precursor,
  • AF421380,
  • ATR,
  • GAPO,
  • anthrax toxin receptor
  • identifiers:
  • 84168,
  • ENSG00000169604,
  • ANTXR1

Genome feature

Region: gene ? Length: 236184  
Location: 2:69013144-69249327 Cyto location: 2p13.3

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2 Diseases

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169 SNPs

5 Cross References

18 Data Sets

4 Homologues

0 Located Features

97 Rna Seq Results