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Gene : CASP9 Homo sapiens

Name  ? caspase 9 Cytological Location  1p36.21
Brief Description  caspase 9
Description  This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein can undergo autoproteolytic processing and activation by the apoptosome, a protein complex of cytochrome c and the apoptotic peptidase activating factor 1; this step is thought to be one of the earliest in the caspase activation cascade. This protein is thought to play a central role in apoptosis and to be a tumor suppressor. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]
  • synonyms:
  • protein phosphatase 1, regulatory subunit 56,
  • caspase 9, apoptosis-related cysteine peptidase,
  • OTTHUMG00000002256,
  • caspase 9, apoptosis-related cysteine protease,
  • HGNC:1511,
  • NM_032996,
  • ICE-LAP6,
  • MCH6,
  • U60521,
  • uc001awn.5,
  • MCH6,
  • PPP1R56,
  • ICE-LAP6,
  • CASP9,
  • APAF-3,
  • PPP1R56,
  • APAF3,
  • APAF-3
  • identifiers:
  • 842,
  • ENSG00000132906,
  • CASP9

Genome feature

Region: gene ? Length: 33512  
Location: 1:15491401-15524912 reverse strand Cyto location: 1p36.21

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0 Diseases

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3756 SN Ps

5 Cross References

17 Data Sets

16 Homologues

1 Located Features

97 Rna Seq Results