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Gene : CASP10 Homo sapiens

Name  ? caspase 10 Cytological Location  2q33.1
Brief Description  caspase 10
Description  This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 3 and 7, and the protein itself is processed by caspase 8. Mutations in this gene are associated with type IIA autoimmune lymphoproliferative syndrome, non-Hodgkin lymphoma and gastric cancer. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Apr 2011]
  • synonyms:
  • ALPS2,
  • CASP10,
  • U60519,
  • MCH4,
  • NM_032977,
  • caspase 10, apoptosis-related cysteine peptidase,
  • FLICE2,
  • OTTHUMG00000132818,
  • caspase 10, apoptosis-related cysteine protease,
  • HGNC:1500,
  • MCH4,
  • uc002uxj.2
  • identifiers:
  • 843,
  • ENSG00000003400,
  • CASP10

Genome feature

Region: gene ? Length: 46522  
Location: 2:201182885-201229406 Cyto location: 2q33.1


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Function

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Gene --> GO terms.

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

Genomics

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Proteins

Gene --> Proteins.

SNPs

Gene Report --> GWAS hit

Disease

3 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

Homology

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Interactions

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Expression

Gene(s) --> Significant SNPs (GTex data)

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Other

3756 SN Ps

5 Cross References

20 Data Sets

18 Homologues

0 Located Features

97 Rna Seq Results