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Gene : CASP10 Homo sapiens

Name  ? caspase 10 Cytological Location  2q33.1
Brief Description  caspase 10
Description  This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 3 and 7, and the protein itself is processed by caspase 8. Mutations in this gene are associated with type IIA autoimmune lymphoproliferative syndrome, non-Hodgkin lymphoma and gastric cancer. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Apr 2011]
  • synonyms:
  • FLICE2,
  • CASP10,
  • uc002uxj.2,
  • MCH4,
  • ALPS2,
  • HGNC:1500,
  • OTTHUMG00000132818,
  • U60519,
  • caspase 10, apoptosis-related cysteine peptidase,
  • MCH4,
  • NM_032977,
  • caspase 10, apoptosis-related cysteine protease
  • identifiers:
  • 843,
  • ENSG00000003400,
  • CASP10

Genome feature

Region: gene ? Length: 46522  
Location: 2:201182885-201229406 Cyto location: 2q33.1

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Gene Ontology Displayer

Gene --> GO terms.

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


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Gene Structure Displayer

Overlapping Features Displayer

Mouse Alleles Displayer

Gene --> Chromosomal location.

Gene --> GO terms.

Gene --> Overlapping genes.


Gene --> Proteins.


Gene Report --> GWAS hit


3 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


Homologue Displayer


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Gene --> Physical and Genetic Interactions


Gene(s) --> Significant SNPs (GTex data)

Gene Ontology

Gene --> GO terms.



3753 SN Ps

5 Cross References

20 Data Sets

8 Homologues

0 Located Features

97 Rna Seq Results