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Gene : DUSP11 Homo sapiens

Name  ? dual specificity phosphatase 11 Cytological Location  2p13.1
Brief Description  dual specificity phosphatase 11
Description  The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product is localized to the nucleus and binds directly to RNA and splicing factors, and thus it is suggested to participate in nuclear mRNA metabolism. [provided by RefSeq, Sep 2008]
  • synonyms:
  • RNA/RNP complex 1-interacting,
  • PIR1,
  • PIR1,
  • OTTHUMG00000129816,
  • dual specificity phosphatase 11 (RNA/RNP complex 1-interacting),
  • DUSP11,
  • AF023917,
  • uc002sjp.4,
  • NM_003584,
  • HGNC:3066
  • identifiers:
  • 8446,
  • ENSG00000144048,
  • DUSP11

Genome feature

Region: gene ? Length: 17960  
Location: 2:73762198-73780157 reverse strand Cyto location: 2p13.1


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Gene --> GO terms.

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

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Proteins

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SNPs

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Disease

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Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

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Expression

Gene(s) --> Significant SNPs (GTex data)

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Other

0 Pathways

770 SN Ps

5 Cross References

16 Data Sets

5 Homologues

0 Located Features

97 Rna Seq Results