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Gene : COL25A1 Homo sapiens

Name  ? collagen type XXV alpha 1 chain Cytological Location  4q25
Brief Description  collagen type XXV alpha 1 chain
Description  This gene encodes a brain-specific membrane associated collagen. A product of proteolytic processing of the encoded protein, CLAC (collagenous Alzheimer amyloid plaque component), binds to amyloid beta-peptides found in Alzheimer amyloid plaques but CLAC inhibits rather than facilitates amyloid fibril elongation (PMID: 16300410). A study of over-expression of this collagen in mice, however, found changes in pathology and behavior suggesting that the encoded protein may promote amyloid plaque formation (PMID: 19548013). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
  • synonyms:
  • AMY,
  • CLAC-P,
  • COL25A1,
  • AF293340,
  • uc062yyf.1,
  • collagen, type XXV, alpha 1,
  • CFEOM5,
  • CLAC,
  • OTTHUMG00000150039,
  • CLACP,
  • NM_032518,
  • HGNC:18603
  • identifiers:
  • 84570,
  • ENSG00000188517,
  • COL25A1

Genome feature

Region: gene ? Length: 494013  
Location: 4:108808725-109302737 reverse strand Cyto location: 4q25


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Disease

1 Diseases

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959 SN Ps

5 Cross References

17 Data Sets

4 Homologues

0 Located Features

97 Rna Seq Results