help  | about  | cite  | software

Gene : HAVCR2 Homo sapiens

Name  ? hepatitis A virus cellular receptor 2 Cytological Location  5q33.3
Brief Description  hepatitis A virus cellular receptor 2
Description  The protein encoded by this gene belongs to the immunoglobulin superfamily, and TIM family of proteins. CD4-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas, Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. This protein is a Th1-specific cell surface protein that regulates macrophage activation, and inhibits Th1-mediated auto- and alloimmune responses, and promotes immunological tolerance. [provided by RefSeq, Sep 2011]
  • synonyms:
  • TIMD3,
  • HAVCR2,
  • HAVcr-2,
  • KIM-3,
  • FLJ14428,
  • NM_032782,
  • Tim-3,
  • HGNC:18437,
  • TIM3,
  • uc003lwk.3,
  • CD366,
  • TIM3,
  • TIMD3,
  • SPTCL,
  • T-cell immunoglobulin mucin family member 3,
  • AK027334,
  • CD366,
  • OTTHUMG00000130249,
  • Tim-3,
  • TIMD-3
  • identifiers:
  • 84868,
  • ENSG00000135077,
  • HAVCR2

Genome feature

Region: gene ? Length: 23213  
Location: 5:157085832-157109044 reverse strand Cyto location: 5q33.3


Uni Prot Comments Displayer

Protein Atlas Displayer

Gene Expression Atlas Tissues Displayer

Gene Expression Atlas Diseases Displayer

Publication Counts Displayer

Curated Proteins Displayer

Function

Gene Ontology Displayer

Gene --> GO terms.

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

Genomics

J Browse Displayer

Gene Structure Displayer

Overlapping Features Displayer

Mouse Alleles Displayer

Gene --> Chromosomal location.

Gene --> GO terms.

Gene --> Overlapping genes.

Proteins

Gene --> Proteins.

SNPs

Gene Report --> GWAS hit

Disease

1 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

Homology

Homologue Displayer

Interactions

Cytoscape Network Displayer

Gene --> Physical and Genetic Interactions

Expression

Gene(s) --> Significant SNPs (GTex data)

Gene Ontology

Gene --> GO terms.

 

Other

505 SN Ps

5 Cross References

18 Data Sets

2 Homologues

0 Located Features

97 Rna Seq Results