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Gene : DEGS1 Homo sapiens

Name  ? delta 4-desaturase, sphingolipid 1 Cytological Location  1q42.11
Brief Description  delta 4-desaturase, sphingolipid 1
Description  This gene encodes a member of the membrane fatty acid desaturase family which is responsible for inserting double bonds into specific positions in fatty acids. This protein contains three His-containing consensus motifs that are characteristic of a group of membrane fatty acid desaturases. It is predicted to be a multiple membrane-spanning protein localized to the endoplasmic reticulum. Overexpression of this gene inhibited biosynthesis of the EGF receptor, suggesting a possible role of a fatty acid desaturase in regulating biosynthetic processing of the EGF receptor. [provided by RefSeq, Mar 2010]
  • synonyms:
  • dihydroceramide desaturase 1,
  • DEGS-1,
  • sphingolipid delta(4)-desaturase 1,
  • OTTHUMG00000037496,
  • DEGS,
  • NM_001321541,
  • AF002668,
  • HGNC:13709,
  • HLD18,
  • FADS7,
  • Des-1,
  • DEGS1,
  • FADS7,
  • MIG15,
  • uc001hoj.4,
  • DES1,
  • DES1,
  • degenerative spermatocyte homolog 1, lipid desaturase (Drosophila),
  • MLD,
  • Des-1,
  • MLD,
  • DEGS-1
  • identifiers:
  • 8560,
  • ENSG00000143753,
  • DEGS1

Genome feature

Region: gene ? Length: 10202  
Location: 1:224183240-224193441 Cyto location: 1q42.11

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1 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


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Gene Ontology

Gene --> GO terms.



3753 SN Ps

5 Cross References

19 Data Sets

9 Homologues

0 Located Features

97 Rna Seq Results