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Gene : ACTL6A Homo sapiens

Name  ? actin like 6A Cytological Location  3q26.33
Brief Description  actin like 6A
Description  This gene encodes a family member of actin-related proteins (ARPs), which share significant amino acid sequence identity to conventional actins. Both actins and ARPs have an actin fold, which is an ATP-binding cleft, as a common feature. The ARPs are involved in diverse cellular processes, including vesicular transport, spindle orientation, nuclear migration and chromatin remodeling. This gene encodes a 53 kDa subunit protein of the BAF (BRG1/brm-associated factor) complex in mammals, which is functionally related to SWI/SNF complex in S. cerevisiae and Drosophila; the latter is thought to facilitate transcriptional activation of specific genes by antagonizing chromatin-mediated transcriptional repression. Together with beta-actin, it is required for maximal ATPase activity of BRG1, and for the association of the BAF complex with chromatin/matrix. Three transcript variants that encode two different protein isoforms have been described. [provided by RefSeq, Jul 2008]
  • synonyms:
  • HGNC:24124,
  • ACTL6A,
  • AK098691,
  • OTTHUMG00000157782,
  • ACTL6,
  • INO80 complex subunit K,
  • BAF53A,
  • BAF complex 53 kDa subunit,
  • Baf53a,
  • BAF53A,
  • NM_004301,
  • BRG1-associated factor,
  • Arp4,
  • INO80K,
  • Arp4,
  • uc003fjw.4,
  • INO80K,
  • Actl6,
  • actin-related protein 4
  • identifiers:
  • 86,
  • ENSG00000136518,
  • ACTL6A

Genome feature

Region: gene ? Length: 25528  
Location: 3:179562880-179588407 Cyto location: 3q26.33

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170 SN Ps

5 Cross References

16 Data Sets

7 Homologues

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97 Rna Seq Results