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Gene : DYNLL1 Homo sapiens

Name  ? dynein light chain LC8-type 1 Cytological Location  12q24.31
Brief Description  dynein light chain LC8-type 1
Description  Cytoplasmic dyneins are large enzyme complexes with a molecular mass of about 1,200 kD. They contain two force-producing heads formed primarily from dynein heavy chains, and stalks linking the heads to a basal domain, which contains a varying number of accessory intermediate chains. The complex is involved in intracellular transport and motility. The protein described in this record is a light chain and exists as part of this complex but also physically interacts with and inhibits the activity of neuronal nitric oxide synthase. Binding of this protein destabilizes the neuronal nitric oxide synthase dimer, a conformation necessary for activity, and it may regulate numerous biologic processes through its effects on nitric oxide synthase activity. Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008]
  • synonyms:
  • LC8,
  • DNCL1,
  • LC8,
  • uc001tyj.4,
  • DYNLL1,
  • NM_003746,
  • U32944,
  • PIN,
  • DLC1,
  • DLC8,
  • hdlc1,
  • DNCLC1,
  • DLC8,
  • hdlc1,
  • OTTHUMG00000169368,
  • HGNC:15476,
  • dynein, cytoplasmic, light polypeptide 1,
  • LC8a,
  • PIN,
  • DNCL1,
  • DLC1
  • identifiers:
  • 8655,
  • ENSG00000088986,
  • DYNLL1

Genome feature

Region: gene ? Length: 28652  
Location: 12:120469842-120498493 Cyto location: 12q24.31

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63 Pathways

Gene --> GO terms.

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


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0 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


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Gene Ontology

Gene --> GO terms.



63 Pathways

626 SN Ps

5 Cross References

16 Data Sets

12 Homologues

0 Located Features

97 Rna Seq Results