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Gene : CBLB Homo sapiens

Name  ? Cbl proto-oncogene B Cytological Location  3q13.11
Brief Description  Cbl proto-oncogene B
Description  This gene encodes an E3 ubiquitin-protein ligase which promotes proteosome-mediated protein degradation by transferring ubiquitin from an E2 ubiquitin-conjugating enzyme to a substrate. The encoded protein is involved in the regulation of immune response by limiting T-cell receptor, B-cell receptor, and high affinity immunoglobulin epsilon receptor activation. Studies in mouse suggest that this gene is involved in antifungal host defense and that its inhibition leads to increased fungal killing. Manipulation of this gene may be beneficial in implementing immunotherapies for a variety of conditions, including cancer, autoimmune diseases, allergies, and infections. [provided by RefSeq, Sep 2017]
  • synonyms:
  • U26710,
  • HGNC:1542,
  • Cbl-b,
  • Cas-Br-M (murine) ecotropic retroviral transforming sequence b,
  • Cbl proto-oncogene B, E3 ubiquitin protein ligase,
  • Nbla00127,
  • CBLB,
  • uc003dwc.4,
  • Cbl-b,
  • Cas-Br-M (murine) ectropic retroviral transforming sequence b,
  • OTTHUMG00000150654,
  • NM_170662,
  • RNF56,
  • RNF56
  • identifiers:
  • 868,
  • ENSG00000114423,
  • CBLB

Genome feature

Region: gene ? Length: 214092  
Location: 3:105655461-105869552 reverse strand Cyto location: 3q13.11


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Function

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Gene --> GO terms.

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

Genomics

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Gene --> Chromosomal location.

Gene --> GO terms.

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Proteins

Gene --> Proteins.

SNPs

Gene Report --> GWAS hit

Disease

0 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

Homology

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Interactions

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Expression

Gene(s) --> Significant SNPs (GTex data)

Gene Ontology

Gene --> GO terms.

 

Other

3756 SN Ps

5 Cross References

18 Data Sets

7 Homologues

0 Located Features

97 Rna Seq Results