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Gene : CTSF Homo sapiens

Name  ? cathepsin F Cytological Location  11q13.2
Brief Description  cathepsin F
Description  Cathepsins are papain family cysteine proteinases that represent a major component of the lysosomal proteolytic system. Cathepsins generally contain a signal sequence, followed by a propeptide and then a catalytically active mature region. The very long (251 amino acid residues) proregion of the cathepsin F precursor contains a C-terminal domain similar to the pro-segment of cathepsin L-like enzymes, a 50-residue flexible linker peptide, and an N-terminal domain predicted to adopt a cystatin-like fold. The cathepsin F proregion is unique within the papain family cysteine proteases in that it contains this additional N-terminal segment predicted to share structural similarities with cysteine protease inhibitors of the cystatin superfamily. This cystatin-like domain contains some of the elements known to be important for inhibitory activity. CTSF encodes a predicted protein of 484 amino acids which contains a 19 residue signal peptide. Cathepsin F contains five potential N-glycosylation sites, and it may be targeted to the endosomal/lysosomal compartment via the mannose 6-phosphate receptor pathway. The cathepsin F gene is ubiquitously expressed, and it maps to chromosome 11q13, close to the gene encoding cathepsin W. [provided by RefSeq, Jul 2008]
  • synonyms:
  • HGNC:2531,
  • CLN13,
  • OTTHUMG00000167090,
  • CATSF,
  • AF071749,
  • CATSF,
  • CTSF,
  • NM_003793,
  • uc001oip.4,
  • CLN13
  • identifiers:
  • 8722,
  • ENSG00000174080,
  • CTSF

Genome feature

Region: gene ? Length: 5144  
Location: 11:66563463-66568606 reverse strand Cyto location: 11q13.2


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Disease

1 Diseases

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3753 SN Ps

5 Cross References

20 Data Sets

6 Homologues

0 Located Features

97 Rna Seq Results