help  | about  | cite  | software

Gene : CDK5R1 Homo sapiens

Name  ? cyclin dependent kinase 5 regulatory subunit 1 Cytological Location  17q11.2
Brief Description  cyclin dependent kinase 5 regulatory subunit 1
Description  The protein encoded by this gene (p35) is a neuron-specific activator of cyclin-dependent kinase 5 (CDK5); the activation of CDK5 is required for proper development of the central nervous system. The p35 form of this protein is proteolytically cleaved by calpain, generating a p25 form. The cleavage of p35 into p25 results in relocalization of the protein from the cell periphery to nuclear and perinuclear regions. P25 deregulates CDK5 activity by prolonging its activation and changing its cellular location. The p25 form accumulates in the brain neurons of patients with Alzheimer's disease. This accumulation correlates with an increase in CDK5 kinase activity, and may lead to aberrantly phosphorylated forms of the microtubule-associated protein tau, which contributes to Alzheimer's disease. [provided by RefSeq, Jul 2008]
  • synonyms:
  • Nck5a,
  • p25,
  • CDK5P35,
  • OTTHUMG00000132814,
  • p23,
  • CDK5R1,
  • NM_003885,
  • p35nck5a,
  • NCK5A,
  • cyclin-dependent kinase 5, regulatory subunit 1 (p35),
  • CDK5R,
  • HGNC:1775,
  • uc002hhn.4,
  • p35nck5a,
  • X80343,
  • p35,
  • p35
  • identifiers:
  • 8851,
  • ENSG00000176749,
  • CDK5R1

Genome feature

Region: gene ? Length: 6229  
Location: 17:32485028-32491256 Cyto location: 17q11.2


Uni Prot Comments Displayer

Protein Atlas Displayer

Gene Expression Atlas Tissues Displayer

Gene Expression Atlas Diseases Displayer

Publication Counts Displayer

Curated Proteins Displayer

Function

Gene Ontology Displayer

Gene --> GO terms.

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

Genomics

J Browse Displayer

Gene Structure Displayer

Overlapping Features Displayer

Mouse Alleles Displayer

Gene --> Chromosomal location.

Gene --> GO terms.

Gene --> Overlapping genes.

Proteins

Gene --> Proteins.

SNPs

Gene Report --> GWAS hit

Disease

0 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

Homology

Homologue Displayer

Interactions

Cytoscape Network Displayer

Gene --> Physical and Genetic Interactions

Expression

Gene(s) --> Significant SNPs (GTex data)

Gene Ontology

Gene --> GO terms.

 

Other

392 SN Ps

5 Cross References

15 Data Sets

6 Homologues

2 Located Features

97 Rna Seq Results