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Gene : BCL10 Homo sapiens

Name  ? BCL10 immune signaling adaptor Cytological Location  1p22.3
Brief Description  BCL10 immune signaling adaptor
Description  This gene was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. The protein encoded by this gene contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]
  • synonyms:
  • CLAP,
  • caspase-recruiting domain-containing protein,
  • B cell CLL/lymphoma 10,
  • CARD-like apoptotic protein,
  • CARD-containing apoptotic signaling protein,
  • IMD37,
  • OTTHUMG00000009965,
  • c-E10,
  • mE10,
  • uc021opd.3,
  • CARMEN,
  • AJ006288,
  • BCL10, immune signaling adaptor,
  • CARMEN,
  • CIPER,
  • CLAP,
  • BCL10,
  • CARD-containing proapoptotic protein,
  • NM_003921,
  • c-E10,
  • HGNC:989,
  • CIPER,
  • CARD containing molecule enhancing NF-kB,
  • mE10
  • identifiers:
  • 8915,
  • ENSG00000142867,
  • BCL10

Genome feature

Region: gene ? Length: 10857  
Location: 1:85265776-85276632 reverse strand Cyto location: 1p22.3


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Disease

5 Diseases

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3756 SN Ps

5 Cross References

19 Data Sets

2 Homologues

0 Located Features

97 Rna Seq Results