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Gene : CCND2 Homo sapiens

Name  ? cyclin D2 Cytological Location  12p13.32
Brief Description  cyclin D2
Description  The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with CDK4 or CDK6 and functions as a regulatory subunit of the complex, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. Knockout studies of the homologous gene in mouse suggest the essential roles of this gene in ovarian granulosa and germ cell proliferation. High level expression of this gene was observed in ovarian and testicular tumors. Mutations in this gene are associated with megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 3 (MPPH3). [provided by RefSeq, Sep 2014]
  • synonyms:
  • MPPH3,
  • uc001qmo.4,
  • OTTHUMG00000168123,
  • AF518005,
  • KIAK0002,
  • HGNC:1583,
  • CCND2,
  • NM_001759,
  • G1/S-specific cyclin D2
  • identifiers:
  • 894,
  • ENSG00000118971,
  • CCND2

Genome feature

Region: gene ? Length: 31592  
Location: 12:4273762-4305353 Cyto location: 12p13.32


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SNPs

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Disease

1 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

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Expression

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65 SN Ps

5 Cross References

19 Data Sets

8 Homologues

0 Located Features

97 Rna Seq Results