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Gene : BTRC Homo sapiens

Name  ? beta-transducin repeat containing E3 ubiquitin protein ligase Cytological Location  10q24.32
Brief Description  beta-transducin repeat containing E3 ubiquitin protein ligase
Description  This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbws class; in addition to an F-box, this protein contains multiple WD-40 repeats. The encoded protein mediates degradation of CD4 via its interaction with HIV-1 Vpu. It has also been shown to ubiquitinate phosphorylated NFKBIA (nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha), targeting it for degradation and thus activating nuclear factor kappa-B. Alternatively spliced transcript variants have been described. A related pseudogene exists in chromosome 6. [provided by RefSeq, Mar 2012]
  • synonyms:
  • Y14153,
  • uc001kta.5,
  • FBXW1A,
  • bTrCP1,
  • FBXW1,
  • HGNC:1144,
  • BTRC,
  • FBXW1A,
  • Fwd1,
  • betaTrCP,
  • bTrCP,
  • OTTHUMG00000018932,
  • betaTrCP,
  • bTrCP,
  • beta-TrCP1,
  • FWD1,
  • beta-transducin repeat containing,
  • bTrCP1,
  • BETA-TRCP,
  • FBW1A,
  • NM_033637
  • identifiers:
  • 8945,
  • ENSG00000166167,
  • BTRC

Genome feature

Region: gene ? Length: 203514  
Location: 10:101353808-101557321 Cyto location: 10q24.32


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Function

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75 Pathways

Gene --> GO terms.

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

Genomics

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Proteins

Gene --> Proteins.

SNPs

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Disease

0 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

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Expression

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Other

75 Pathways

3753 SN Ps

5 Cross References

17 Data Sets

0 Homologues

0 Located Features

97 Rna Seq Results