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Gene : CCNE1 Homo sapiens

Name  ? cyclin E1 Cytological Location  19q12
Brief Description  cyclin E1
Description  The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2, whose activity is required for cell cycle G1/S transition. This protein accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. Overexpression of this gene has been observed in many tumors, which results in chromosome instability, and thus may contribute to tumorigenesis. This protein was found to associate with, and be involved in, the phosphorylation of NPAT protein (nuclear protein mapped to the ATM locus), which participates in cell-cycle regulated histone gene expression and plays a critical role in promoting cell-cycle progression in the absence of pRB. [provided by RefSeq, Apr 2016]
  • synonyms:
  • cyclin Et,
  • OTTHUMG00000177626,
  • CCNE,
  • uc002nsn.4,
  • CCNE,
  • pCCNE1,
  • CCNE1,
  • M73812,
  • NM_001238,
  • HGNC:1589,
  • cyclin Es
  • identifiers:
  • 898,
  • ENSG00000105173,
  • CCNE1

Genome feature

Region: gene ? Length: 12322  
Location: 19:29811991-29824312 Cyto location: 19q12


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44 Pathways

Gene --> GO terms.

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Proteins

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SNPs

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Disease

0 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

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Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

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Expression

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Other

44 Pathways

3740 SNPs

5 Cross References

16 Data Sets

9 Homologues

0 Located Features

97 Rna Seq Results