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Gene : CCNH Homo sapiens

Name  ? cyclin H Cytological Location  5q14.3
Brief Description  cyclin H
Description  The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with CDK7 kinase and ring finger protein MAT1. The kinase complex is able to phosphorylate CDK2 and CDC2 kinases, thus functions as a CDK-activating kinase (CAK). This cyclin and its kinase partner are components of TFIIH, as well as RNA polymerase II protein complexes. They participate in two different transcriptional regulation processes, suggesting an important link between basal transcription control and the cell cycle machinery. A pseudogene of this gene is found on chromosome 4. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Nov 2010]
  • synonyms:
  • p37,
  • p37,
  • HGNC:1594,
  • cyclin-dependent kinase-activating kinase complex subunit,
  • p34,
  • p34,
  • uc003kjb.4,
  • U12685,
  • OTTHUMG00000119077,
  • CAK,
  • CDK-activating kinase complex subunit,
  • CycH,
  • NM_001239,
  • CycH,
  • CAK complex subunit,
  • CCNH,
  • MO15-associated protein
  • identifiers:
  • 902,
  • ENSG00000134480,
  • CCNH

Genome feature

Region: gene ? Length: 101501  
Location: 5:87311471-87412971 reverse strand Cyto location: 5q14.3

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60 Pathways

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60 Pathways

425 SNPs

5 Cross References

17 Data Sets

6 Homologues

0 Located Features

97 Rna Seq Results