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Gene : CCNT1 Homo sapiens

Name  ? cyclin T1 Cytological Location  12q13.11-q13.12
Brief Description  cyclin T1
Description  This gene encodes a member of the highly conserved cyclin C subfamily. The encoded protein tightly associates with cyclin-dependent kinase 9, and is a major subunit of positive transcription elongation factor b (p-TEFb). In humans, there are multiple forms of positive transcription elongation factor b, which may include one of several different cyclins along with cyclin-dependent kinase 9. The complex containing the encoded cyclin and cyclin-dependent kinase 9 acts as a cofactor of human immunodeficiency virus type 1 (HIV-1) Tat protein, and is both necessary and sufficient for full activation of viral transcription. This cyclin and its kinase partner are also involved in triggering transcript elongation through phosphorylation of the carboxy-terminal domain of the largest RNA polymerase II subunit. Overexpression of this gene is implicated in tumor growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2013]
  • synonyms:
  • human immunodeficiency virus type 1 (HIV-1) expression (elevated) 1,
  • CYCT1,
  • HGNC:1599,
  • HIVE1,
  • NM_001240,
  • OTTHUMG00000170393,
  • CCNT,
  • HIVE1,
  • AF048730,
  • uc001rsd.5,
  • CCNT,
  • CCNT1,
  • CYCT1
  • identifiers:
  • 904,
  • ENSG00000129315,
  • CCNT1

Genome feature

Region: gene ? Length: 28250  
Location: 12:48688458-48716707 reverse strand Cyto location: 12q13.11-q13.12


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180 SNPs

5 Cross References

16 Data Sets

8 Homologues

6 Located Features

97 Rna Seq Results