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Gene : ARTN Homo sapiens

Name  ? artemin Cytological Location  1p34.1
Brief Description  artemin
Description  This gene encodes a secreted ligand of the glial cell line-derived neurotrophic factor (GDNF) subfamily and TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein signals through the RET receptor and GFR alpha 3 coreceptor, and supports the survival of a number of peripheral neuron populations and at least one population of dopaminergic CNS neurons. This protein has also been shown to promote tumor growth, metastasis, and drug resistance in mammary carcinoma. [provided by RefSeq, Aug 2016]
  • synonyms:
  • NBN,
  • NM_057090,
  • ART,
  • neurotrophic factor,
  • NBN,
  • uc001ckv.4,
  • EVN,
  • EVN,
  • ARTN,
  • neublastin,
  • AF109401,
  • OTTHUMG00000007705,
  • HGNC:727
  • identifiers:
  • 9048,
  • ENSG00000117407,
  • ARTN

Genome feature

Region: gene ? Length: 3440  
Location: 1:43933801-43937240 Cyto location: 1p34.1

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0 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

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Mouse Gene --> Allele [Phenotype]


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3740 SN Ps

5 Cross References

15 Data Sets

2 Homologues

0 Located Features

97 Rna Seq Results