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Gene : CLDN8 Homo sapiens

Name  ? claudin 8 Cytological Location  21q22.11
Brief Description  claudin 8
Description  This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This protein plays important roles in the paracellular cation barrier of the distal renal tubule, and in the paracellular barrier to prevent sodium back-leakage in distal colon. Differential expression of this gene has been observed in colorectal carcinoma and renal cell tumors, and along with claudin-7, is an immunohistochemical marker for the differential diagnosis of chromophobe renal cell carcinoma and renal oncocytoma.[provided by RefSeq, May 2010]
  • synonyms:
  • CLDN8,
  • HGNC:2050,
  • HEL-S-79,
  • NM_199328,
  • uc002ynu.3,
  • AJ250711,
  • OTTHUMG00000081872
  • identifiers:
  • 9073,
  • ENSG00000156284,
  • CLDN8

Genome feature

Region: gene ? Length: 2092  
Location: 21:30214006-30216097 reverse strand Cyto location: 21q22.11


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Proteins

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SNPs

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Disease

0 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

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Gene -> HPO annotation (Human Phenotype Ontology)

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Expression

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Other

3753 SN Ps

5 Cross References

17 Data Sets

4 Homologues

0 Located Features

97 Rna Seq Results