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Gene : CD1E Homo sapiens

Name  ? CD1e molecule Cytological Location  1q23.1
Brief Description  CD1e molecule
Description  This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes within Golgi compartments, endosomes, and lysosomes, and is cleaved into a stable soluble form. The soluble form is required for the intracellular processing of some glycolipids into a form that can be presented by other CD1 family members. Many alternatively spliced transcript variants encoding different isoforms have been described. Additional transcript variants have been found; however, their biological validity has not been determined. [provided by RefSeq, Jun 2010]
  • synonyms:
  • uc001fse.4,
  • NM_030893,
  • CD1e antigen,
  • AJ289111,
  • HGNC:1638,
  • CD1E,
  • R2,
  • CD1A,
  • OTTHUMG00000017515,
  • CD1E antigen, e polypeptide
  • identifiers:
  • 913,
  • ENSG00000158488,
  • CD1E

Genome feature

Region: gene ? Length: 4432  
Location: 1:158353123-158357554 Cyto location: 1q23.1


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0 Pathways

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Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

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Proteins

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SNPs

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Disease

0 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

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Expression

Gene(s) --> Significant SNPs (GTex data)

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Other

0 Pathways

3740 SN Ps

5 Cross References

16 Data Sets

21 Homologues

0 Located Features

97 Rna Seq Results