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Gene : CBFA2T2 Homo sapiens

Name  ? CBFA2/RUNX1 partner transcriptional co-repressor 2 Cytological Location  20q11.21-q11.22
Brief Description  CBFA2/RUNX1 partner transcriptional co-repressor 2
Description  In acute myeloid leukemia, especially in the M2 subtype, the t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 (AML1) gene fused to the 3'-region of the CBFA2T1 (MTG8) gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. The protein encoded by this gene binds to the AML1-MTG8 complex and may be important in promoting leukemogenesis. Several transcript variants are thought to exist for this gene, but the full-length natures of only three have been described. [provided by RefSeq, Jul 2008]
  • synonyms:
  • HGNC:1536,
  • NM_001032999,
  • EHT,
  • MTGR1,
  • uc002wze.2,
  • p85,
  • AF052210,
  • CBFA2T2,
  • OTTHUMG00000032261,
  • CBFA2/RUNX1 translocation partner 2,
  • MTGR1,
  • core-binding factor, runt domain, alpha subunit 2; translocated to, 2,
  • ZMYND3,
  • ZMYND3
  • identifiers:
  • 9139,
  • ENSG00000078699,
  • CBFA2T2

Genome feature

Region: gene ? Length: 159962  
Location: 20:33490070-33650031 Cyto location: 20q11.21-q11.22


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Disease

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Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

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Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

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Expression

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0 Pathways

3753 SN Ps

5 Cross References

17 Data Sets

3 Homologues

0 Located Features

97 Rna Seq Results