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Gene : CD3E Homo sapiens

Name  ? CD3e molecule Cytological Location  11q23.3
Brief Description  CD3e molecule
Description  The protein encoded by this gene is the CD3-epsilon polypeptide, which together with CD3-gamma, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. Defects in this gene cause immunodeficiency. This gene has also been linked to a susceptibility to type I diabetes in women. [provided by RefSeq, Jul 2008]
  • synonyms:
  • NM_000733,
  • uc001psq.5,
  • T3E,
  • TCRE,
  • CD3e molecule, epsilon (CD3-TCR complex),
  • HGNC:1674,
  • CD3E,
  • IMD18,
  • OTTHUMG00000166968,
  • X03884,
  • CD3e antigen, epsilon polypeptide (TiT3 complex)
  • identifiers:
  • 916,
  • ENSG00000198851,
  • CD3E

Genome feature

Region: gene ? Length: 11444  
Location: 11:118304730-118316173 Cyto location: 11q23.3


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Function

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Gene --> GO terms.

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

Genomics

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Gene --> Chromosomal location.

Gene --> GO terms.

Gene --> Overlapping genes.

Proteins

Gene --> Proteins.

SNPs

Gene Report --> GWAS hit

Disease

1 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

Homology

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Interactions

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Gene --> Physical and Genetic Interactions

Expression

Gene(s) --> Significant SNPs (GTex data)

Gene Ontology

Gene --> GO terms.

 

Other

231 SN Ps

5 Cross References

19 Data Sets

2 Homologues

0 Located Features

97 Rna Seq Results