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Gene : CD4 Homo sapiens

Name  ? CD4 molecule Cytological Location  12p13.31
Brief Description  CD4 molecule
Description  This gene encodes the CD4 membrane glycoprotein of T lymphocytes. The CD4 antigen acts as a coreceptor with the T-cell receptor on the T lymphocyte to recognize antigens displayed by an antigen presenting cell in the context of class II MHC molecules. The CD4 antigen is also a primary receptor for entry of the human immunodeficiency virus through interactions with the HIV Env gp120 subunit. This gene is expressed not only in T lymphocytes, but also in B cells, macrophages, granulocytes, as well as in various regions of the brain. The protein functions to initiate or augment the early phase of T-cell activation, and may function as an important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, May 2020]
  • synonyms:
  • T-cell surface glycoprotein CD4,
  • HGNC:1678,
  • CD4 antigen (p55),
  • NM_000616,
  • uc001qqv.3,
  • CD4,
  • M35160,
  • CD4mut,
  • OTTHUMG00000168514
  • identifiers:
  • 920,
  • ENSG00000010610,
  • CD4

Genome feature

Region: gene ? Length: 31272  
Location: 12:6789528-6820799 Cyto location: 12p13.31


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Proteins

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SNPs

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Disease

1 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

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Gene -> HPO annotation (Human Phenotype Ontology)

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Expression

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Other

362 SN Ps

5 Cross References

19 Data Sets

12 Homologues

0 Located Features

97 Rna Seq Results