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Gene : DLG5 Homo sapiens

Name  ? discs large MAGUK scaffold protein 5 Cytological Location  10q22.3
Brief Description  discs large MAGUK scaffold protein 5
Description  This gene encodes a member of the family of discs large (DLG) homologs, a subset of the membrane-associated guanylate kinase (MAGUK) superfamily. The MAGUK proteins are composed of a catalytically inactive guanylate kinase domain, in addition to PDZ and SH3 domains, and are thought to function as scaffolding molecules at sites of cell-cell contact. The protein encoded by this gene localizes to the plasma membrane and cytoplasm, and interacts with components of adherens junctions and the cytoskeleton. It is proposed to function in the transmission of extracellular signals to the cytoskeleton and in the maintenance of epithelial cell structure. Alternative splice variants have been described but their biological nature has not been determined. [provided by RefSeq, Jul 2008]
  • synonyms:
  • OTTHUMG00000018548,
  • NM_004747,
  • uc001jzk.4,
  • P-dlg,
  • DLG5,
  • PDLG,
  • LP-DLG,
  • KIAA0583,
  • HGNC:2904,
  • discs large homolog 5,
  • discs, large homolog 5 (Drosophila),
  • P-DLG5,
  • U61843
  • identifiers:
  • 9231,
  • ENSG00000151208,
  • DLG5

Genome feature

Region: gene ? Length: 135969  
Location: 10:77790787-77926755 reverse strand Cyto location: 10q22.3


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Function

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0 Pathways

Gene --> GO terms.

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

Genomics

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Proteins

Gene --> Proteins.

SNPs

Gene Report --> GWAS hit

Disease

0 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

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Expression

Gene(s) --> Significant SNPs (GTex data)

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Other

0 Pathways

3753 SN Ps

5 Cross References

16 Data Sets

6 Homologues

0 Located Features

97 Rna Seq Results